Affiliation:
1. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China
2. School of Applied Chemistry and Engineering University of Science and Technology of China Hefei 230026 China
3. Key Laboratory of Superlight Materials & Surface Technology of Ministry of Education College of Material Sciences and Chemical Engineering Harbin Engineering University Harbin 150001 China
Abstract
AbstractMesoporous silica nanoparticles (MSNs) have been widely praised as nanoadjuvants in vaccine/tumor immunotherapy thanks to their excellent biocompatibility, easy‐to‐modify surface, adjustable particle size, and remarkable immuno‐enhancing activity. However, the application of MSNs is still greatly limited by some severe challenges including the unclear and complicated relationships of structure and immune effect. Herein, three commonly used MSNs with different skeletons including MSN with tetrasulfide bonds (TMSN), MSN containing ethoxy framework (EMSN), and pure −Si−O−Si− framework of MSN (MSN) are comprehensively compared to study the impact of chemical construction on immune effect. The results fully demonstrate that the three MSNs have great promise in improving cellular immunity for tumor immunotherapy. Moreover, the TMSN performs better than the other two MSNs in antigen loading, cellular uptake, reactive oxygen species (ROS) generation, lymph node targeting, immune activation, and therapeutic efficiency. The findings provide a new paradigm for revealing the structure‐function relationship of mesoporous silica nanoadjuvants, paving the way for their future clinical application.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry