Nanotransducer‐Enabled Wireless Spatiotemporal Tuning of Engineered Bacteria in Bumblebee

Author:

Cheng Xiaowen123,Wang Chen23,Yang Junzhu23,Liu Dong23,Liao Yuting23,Wang Bin23,Han Sanyang4,Zhang Xue5,Zheng Hao1,Lu Yuan23ORCID

Affiliation:

1. College of Food Science and Nutritional Engineering China Agricultural University Beijing 100083 China

2. Key Laboratory of Industrial Biocatalysis Ministry of Education Tsinghua University Beijing 100084 China

3. Department of Chemical Engineering Tsinghua University Beijing 100084 China

4. Institute of Biopharmaceutical and Health Engineering Shenzhen International Graduate School Tsinghua University Shenzhen 518055 China

5. College of Plant Protection China Agricultural University Beijing 100083 China

Abstract

AbstractBumblebees are essential pollinators of wild‐flowering plants and crops. It is noticed that regulating the gut microorganisms of bumblebees is of great significance for the maintenance of bumblebee health and disease treatment. Additionally, social bees are used as models to study regulatory control methods of gut bacteria in vivo. However, these methods lack precision and are not studied in bumblebees. In this study, nanotransducers are used for wireless spatiotemporal tuning of engineered bacteria in bumblebees. These nanotransducers are designed as 1D chains with smooth surfaces for easy transport in vivo, and temperature‐controlled engineered bacteria colonize the guts of microbial‐free bumblebees. Thermal production in the bumblebee gut is achieved using magnetothermal and photothermal methods in response to nanotransducers, resulting in significant target protein upregulation in engineered bacteria in the bumblebee gut. This advanced technology enables the precise control of engineered bacteria in the bumblebee gut. It also lays the foundation for the treatment of bumblebee intestinal parasitic diseases and the elimination of pesticide residues.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

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