Aggregates of Ionic‐Bonds Coupled Polymer and Their Photosensitization Enhancement Effect

Abstract

The formation of nanoaggregates makes a great difference to the improvement of photodynamic therapy (PDT) performance to some extent, but constructing stable aggregates with a clear structure is simultaneously a big challenge for us. Herein, just by electrostatic interaction, cationic 2PAHs and anionic FBA351, regarded as acceptor (A) and donor (D), respectively, are utilized to prepare stable aggregate of ionic‐bonds coupled polymer (ICP) with repeated “D–A” structure, which is fully characterized by nuclear magnetic resonance (NMR), time‐of‐flight mass spectrometry, X‐ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM). Remarkably, aggregate ICP with multiple “D–A” structures showed enhanced photosensitization efficiency over its precursor 2PAHs and FBA351, which is in accord with the image‐guided photodynamic anticancer therapy. Such results not only offer a simple way to obtain stable aggregate but also give us a guideline to design efficient photosensitizers.