3D Printed Multifunctional Biomimetic Bone Scaffold Combined with TP‐Mg Nanoparticles for the Infectious Bone Defects Repair

Author:

Hu Xulin12,Chen Jiao3,Yang Shuhao4,Zhang Zhen5,Wu Haoming1,He Jian6,Qin Leilei4,Cao Jianfei7,Xiong Chengdong5,Li Kainan1,Liu Xian3,Qian Zhiyong2ORCID

Affiliation:

1. Clinical Medical College and Affiliated Hospital of Chengdu University Chengdu University Chengdu Sichuan 610081 China

2. Department of Biotherapy Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu Sichuan 610041 China

3. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan 610041 China

4. Department of Orthopedics The First Affiliated Hospital of Chongqing Medical University Chongqing 400042 China

5. University of Chinese Academy of Sciences Beijing 101408 China

6. College of Medical Henan University of Science and Technology Luoyang 471023 China

7. School of Materials and Environmental Engineering Chengdu Technological University Chengdu Sichuan 611730 China

Abstract

AbstractInfected bone defects are one of the most challenging problems in the treatment of bone defects due to the high antibiotic failure rate and the lack of ideal bone grafts. In this paper, inspired by clinical bone cement filling treatment, α‐c phosphate (α‐TCP) with self‐curing properties is composited with β‐tricalcium phosphate (β‐TCP) and constructed a bionic cancellous bone scaffolding system α/β‐tricalcium phosphate (α/β‐TCP) by low‐temperature 3D printing, and gelatin is preserved inside the scaffolds as an organic phase, and later loaded with a metal–polyphenol network structure of tea polyphenol‐magnesium (TP‐Mg) nanoparticles. The scaffolds mimic the structure and components of cancellous bone with high mechanical strength (>100 MPa) based on α‐TCP self‐curing properties through low‐temperature 3D printing. Meanwhile, the scaffolds loaded with TP‐Mg exhibit significant inhibition of Staphylococcus aureus (S.aureus) and promote the transition of macrophages from M1 pro‐inflammatory to M2 anti‐inflammatory phenotype. In addition, the composite scaffold also exhibits excellent bone‐enhancing effects based on the synergistic effect of Mg2+ and Ca2+. In this study, a multifunctional ceramic scaffold (α/β‐TCP@TP‐Mg) that integrates anti‐inflammatory, antibacterial, and osteoinduction is constructed, which promotes late bone regenerative healing while modulating the early microenvironment of infected bone defects, has a promising application in the treatment of infected bone defects.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Sichuan Province

Publisher

Wiley

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