Affiliation:
1. College of Chemistry and Molecular Sciences Wuhan University Wuhan 430072 P. R. China
2. Marshall Laboratory of Biomedical Engineering International Cancer Center Laboratory of Evolutionary Theranostics (LET) School of Biomedical Engineering Shenzhen University Medical School Shenzhen University Shenzhen 518055 P. R. China
3. State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular Recognition Research Center for Analytical Sciences College of Chemistry Nankai University Tianjin 300071 P. R. China
4. Hubei Jiangxia Laboratory Wuhan 430200 P. R. China
Abstract
AbstractDeveloping the second near‐infrared (NIR‐II) photoacoustic (PA) agent is of great interest in bioimaging. Ag2Se quantum dots (QDs) are one kind of potential probe for applications in NIR‐II photoacoustic imaging (PAI). However, the surfaces with excess anions of Ag2Se QDs, which increase the probability of nonradiative transitions of excitons benefiting PA imaging, are not conducive to binding electron donor ligands for potential biolabeling and imaging. In this study, Staphylococcus aureus (S. aureus) cells are driven for the biosynthesis of Ag2Se QDs with catalase (CAT). Biosynthesized Ag2Se (bio‐Ag2Se‐CAT) QDs are produced in Se‐enriched environment of S. aureus and have a high Se‐rich surface. The photothermal conversion efficiency of bio‐Ag2Se‐CAT QDs at 808 and 1064 nm is calculated as 75.3% and 51.7%, respectively. Additionally, the PA signal responsiveness of bio‐Ag2Se‐CAT QDs is ≈10 times that of the commercial PA contrast agent indocyanine green. In particular, the bacterial CAT is naturally attached to bio‐Ag2Se‐CAT QDs surface, which can effectively relieve tumor hypoxia. The bio‐Ag2Se‐CAT QDs can relieve heat‐initiated oxidative stress while undergoing effective photothermal therapy (PTT). Such biosynthesis method of NIR‐II bio‐Ag2Se‐CAT QDs opens a new avenue for developing multifunctional nanomaterials, showing great promise for PAI, hypoxia alleviation, and PTT.
Funder
National Key Research and Development Program of China
National Natural Science Foundation of China
Cited by
1 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献