Highly Sensitive Wearable Sensor Based on (001)‐Orientated TiO2 for Real‐Time Electrochemical Detection of Dopamine, Tyrosine, and Paracetamol

Author:

Zhang Tianyao1,Zhu Jia123,Xie Maowen1,Meng Ke1,Yao Guang1,Pan Taisong1,Gao Min1,Cheng Huanyu3ORCID,Lin Yuan14ORCID

Affiliation:

1. School of Material and Energy University of Electronic Science and Technology of China Chengdu 610054 China

2. Yangtze Delta Region Institute (Quzhou) University of Electronic Science and Technology of China Quzhou 324000 China

3. Department of Engineering Science and Mechanics The Pennsylvania State University University Park Pennsylvania 16802 USA

4. Medico‐Engineering Cooperation on Applied Medicine Research Center University of Electronics Science and Technology of China Chengdu 610054 China

Abstract

AbstractThe concentration of dopamine (DA) and tyrosine (Tyr) reflects the condition of patients with Parkinson's disease, whereas moderate paracetamol (PA) can help relieve their pain. Therefore, real‐time measurements of these bioanalytes have important clinical implications for patients with Parkinson's disease. However, previous sensors suffer from either limited sensitivity or complex fabrication and integration processes. This work introduces a simple and cost‐effective method to prepare high‐quality, flexible titanium dioxide (TiO2) thin films with highly reactive (001)‐facets. The as‐fabricated TiO2 film supported by a carbon cloth electrode (i.e., TiO2–CC) allows excellent electrochemical specificity and sensitivity to DA (1.390 µA µM−1 cm−2), Tyr (0.126 µA µM−1 cm−2), and PA (0.0841 µA µM−1 cm−2). More importantly, accurate DA concentration in varied pH conditions can be obtained by decoupling them within a single differential pulse voltammetry measurement without additional sensing units. The TiO2–CC electrochemical sensor can be integrated into a smart diaper to detect the trace amount of DA or an integrated skin‐interfaced patch with microfluidic sampling and wireless transmission units for real‐time detection of the sweat Try and PA concentration. The wearable sensor based on TiO2–CC prepared by facile manufacturing methods holds great potential in the daily health monitoring and care of patients with neurological disorders.

Funder

National Natural Science Foundation of China

National Institutes of Health

National Science Foundation

Pennsylvania State University

Publisher

Wiley

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