A facile Immunoregulatory Constructional Design by Proanthocyanidin Optimizing Directional Chitosan Microchannel

Author:

Li Xing12,Wang Yuxiang12,Zhao Chengkun12,Tong Lei12,Wang Peilei12,Liang Jie123,Jiang Qing12,Fan Yujiang12,Zhang Xingdong12,Sun Yong12ORCID

Affiliation:

1. CAE/NAE National Engineering Research Center for Biomaterials Sichuan University 29# Wangjiang Road Chengdu Sichuan 610064 P. R. China

2. College of Biomedical Engineering Sichuan University 29# Wangjiang Road Chengdu Sichuan 610064 P. R. China

3. Sichuan Testing Center for Biomaterials and Medical Devices Sichuan University 29# Wangjiang Road Chengdu 610064 P. R. China

Abstract

AbstractImproving the interconnected structure and bioregulatory function of natural chitosan is beneficial for optimizing its performance in bone regeneration. Here, a facile immunoregulatory constructional design is proposed for developing instructive chitosan by directional freezing and alkaline salting out. The molecular dynamics simulation confirmed the assembly kinetics and structural features of various polyphenols and chitosan molecules. Along with the in vitro anti‐inflammatory, antioxidative, promoting bone mesenchymal stem cell (BMSC) adhesion and proliferation performance, proanthocyanidin optimizing chitosan (ChiO) scaffold presented an optimal immunoregulatory structure with the directional microchannel. Transcriptome analysis in vitro further revealed the cytoskeleton‐ and immune‐regulation effect of ChiO are the key mechanism of action on BMSC. The rabbit cranial defect model (Φ = 10 mm) after 12 weeks of implantation confirmed the significantly enhanced bone reconstitution. This facile immunoregulatory directional microchannel design provides effective guidance for developing inducible chitosan scaffolds.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Wiley

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