Recapitulating Antioxidant and Antibacterial Compounds into a Package for Tissue Regeneration: Dual Function Materials with Synergistic Effect

Author:

Shao Minmin1,Bigham Ashkan2,Yousefiasl Satar3,Yiu Cynthia K. Y.4,Girish Yarabahally R.5,Ghomi Matineh6,Sharifi Esmaeel7,Sezen Serap8,Nazarzadeh Zare Ehsan6ORCID,Zarrabi Ali9ORCID,Rabiee Navid1011,Paiva‐Santos Ana Cláudia1213ORCID,Del Turco Serena1415,Guo Baolin1617,Wang Xiangdong18,Mattoli Virgilio15,Wu Aimin19

Affiliation:

1. Department of Otorhinolaryngology The Second Affiliated Hospital of Shanghai University Wenzhou Central Hospital Wenzhou 325000 P. R. China

2. Institute of Polymers Composites and Biomaterials National Research Council (IPCB‐CNR) 80125 Naples Italy

3. School of Dentistry Hamadan University of Medical Sciences Hamadan 6517838736 Iran

4. Paediatric Dentistry and Orthodontics Faculty of Dentistry The University of Hong Kong Prince Philip Dental Hospital Hong Kong 999077 P. R. China

5. Centre for Research and Innovations School of Natural Sciences BGSIT Adichunchanagiri University B.G. Nagara, Mandya District Mandya Karnataka 571448 India

6. School of Chemistry Damghan University Damghan 36716‐45667 Iran

7. Department of Tissue Engineering and Biomaterials School of Advanced Medical Sciences and Technologies Hamadan University of Medical Sciences Hamadan 6517838736 Iran

8. Faculty of Engineering and Natural Sciences Sabanci University Orta Mahalle, Üniversite Caddesi No. 27, Orhanlı Tuzla Istanbul 34956 Turkey

9. Department of Biomedical Engineering Faculty of Engineering and Natural Sciences Istinye University Sariyer Istanbul 34396 Turkey

10. Centre for Molecular Medicine and Innovative Therapeutics Murdoch University Perth Western Australia 6150 Australia

11. School of Engineering Macquarie University Sydney New South Wales 2109 Australia

12. Department of Pharmaceutical Technology Faculty of Pharmacy of the University of Coimbra University of Coimbra 3000‐548 Coimbra Portugal

13. REQUIMTE/LAQV Group of Pharmaceutical Technology Faculty of Pharmacy of the University of Coimbra University of Coimbra 3000‐548 Coimbra Portugal

14. National Research Council Institute of Clinical Physiology 56124 Pisa Italy

15. Istituto Italiano di Tecnologia Centre for Materials Interfaces 56025 Pontedera Pisa Italy

16. State Key Laboratory for Mechanical Behavior of Materials and Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an 710049 P. R. China

17. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of Stomatology Xi'an Jiaotong University Xi'an 710049 P. R. China

18. Department of Pulmonary and Critical Care Medicine Zhongshan Hospital Fudan University Shanghai Medical College Shanghai 200032 P. R. China

19. Department of Orthopaedics Key Laboratory of Structural Malformations in Children of Zhejiang Province Key Laboratory of Orthopaedics of Zhejiang Province The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou Zhejiang Province 325000 P. R. China

Abstract

AbstractOxidative damage and infection can prevent or delay tissue repair. Moreover, infection reinforces reactive oxygen species (ROS) formation, which makes the wound's condition even worse. Therefore, the need for antioxidant and antibacterial agents is felt for tissue regeneration. There are emerging up‐and‐coming biomaterials that recapitulate both properties into a package, offering an effective solution to turn the wound back into a healing state. In this article, the principles of antioxidant and antibacterial activity are summarized. The review starts with biological aspects, getting the readers to familiarize themselves with tissue barriers against infection. This is followed by the chemistry and mechanism of action of antioxidant and antibacterial materials (dual function). Eventually, the outlook and challenges are underlined to provide where the dual‐function biomaterials are and where they are going in the future. It is expected that the present article inspires the designing of dual‐function biomaterials to more advanced levels by providing the fundamentals and comparative points of view and paving the clinical way for these materials.

Funder

National Natural Science Foundation of China

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

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