Emergency Treatment and Photoacoustic Assessment of Spinal Cord Injury Using Reversible Dual‐Signal Transform‐Based Selenium Antioxidant

Author:

Ji Zhisheng1,Zheng Judun2,Ma Yanming1,Lei Hongyi3,Lin Weiqiang2,Huang Jialin2,Yang Hua1,Zhang Guowei1,Li Bin2,Shu Bowen2,Du Xianjin4,Zhang Jian5,Lin Hongsheng1,Liao Yuhui236ORCID

Affiliation:

1. Department of Orthopedics The First Affiliated Hospital of Jinan University Guangzhou 510630 P. R. China

2. Molecular Diagnosis and Treatment Center for Infectious Diseases Dermatology Hospital Southern Medical University Guangzhou 510091 P. R. China

3. Department of Anesthesiology Longgang District Central Hospital of Shenzhen Shenzhen 518100 P. R. China

4. Department of Critical Care Medicine Renmin Hospital of Wuhan University Wuhan Hubei 430060 P. R. China

5. Department of Biomedical Engineering School of Basic Medical Science Guang‐zhou Medical University Guangzhou 511436 P. R. China

6. NHC Key Laboratory of Metabolic Cardiovascular Diseases Research Ningxia Key Laboratory of Vascular Injury and Repair Research Ningxia Medical University Yinchuan 750004 P. R. China

Abstract

AbstractSpinal cord injury (SCI), following explosive oxidative stress, causes an abrupt and irreversible pathological deterioration of the central nervous system. Thus, preventing secondary injuries caused by reactive oxygen species (ROS), as well as monitoring and assessing the recovery from SCI are critical for the emergency treatment of SCI. Herein, an emergency treatment strategy is developed for SCI based on the selenium (Se) matrix antioxidant system to effectively inhibit oxidative stress‐induced damage and simultaneously real‐time evaluate the severity of SCI using a reversible dual‐photoacoustic signal (680 and 750 nm). Within the emergency treatment and photoacoustic severity assessment (ETPSA) strategy, the designed Se loaded boron dipyrromethene dye with a double hydroxyl group (Se@BDP‐DOH) is simultaneously used as a sensitive reporter group and an excellent antioxidant for effectively eliminating explosive oxidative stress. Se@BDP‐DOH is found to promote the recovery of both spinal cord tissue and locomotor function in mice with SCI. Furthermore, ETPSA strategy synergistically enhanced ROS consumption via the caveolin 1 (Cav 1)‐related pathways, as confirmed upon treatment with Cav 1 siRNA. Therefore, the ETPSA strategy is a potential tool for improving emergency treatment and photoacoustic assessment of SCI.

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Natural Science Foundation of Guangdong Province for Distinguished Young Scholars

National Science Foundation

Publisher

Wiley

Subject

Biomaterials,Biotechnology,General Materials Science,General Chemistry

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