An Integrated Nanoplatform via Dual Channel Excitation for Both Precise Fluorescence Imaging and Photodynamic Therapy of Orthotopic Breast Tumor in NIR‐II Region

Author:

Lv Kehong12,Wang Hongli3,Fu Xinyu12,Chen Shengzhe12,Zhang Ruohao12,Zhou Yifei12,Feng Jing12,Zhang Hongjie124ORCID

Affiliation:

1. State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 P. R. China

2. School of Applied Chemistry and Engineering University of Science and Technology of China Hefei 230026 P. R. China

3. College of Animal Science Jilin University Changchun Jilin 130062 P. R. China

4. Department of Chemistry Tsinghua University Beijing 100084 P. R. China

Abstract

AbstractAlthough research on photodynamic therapy (PDT) of malignant tumor has made considerable progress in recent years, it is a remaining challenge to extend PDT to the second near‐infrared window (NIR‐II) along with real‐time and accurate NIR‐II fluorescence imaging to determine drug enrichment status and achieve high treatment efficacy. In this work, lanthanide nanoparticles (Ln NPs)‐based nanoplatform (LCR) equipped with photosensitizer Chlorin e6 (Ce6) and targeting molecular NH2‐PEG1000‐cRGDfK are developed, which can achieve NIR‐II photodynamic therapy (PDT) and NIR‐II fluorescence imaging by dual channel excitation. Under 808 nm excitation, Nd3+ in the outer layer can absorb the energy and transfer inward to emit strong NIR‐II emissions (1064 and 1525 nm). Due to the low background noise of NIR‐II light and the targeting effect of NH2‐PEG1000‐cRGDfK, LCR can recognize tiny tumor tissue (≈3 mm) and monitor drug distribution in vivo. Under 1530 nm excitation, internal Er3+ can be self‐sensitized, generating intense upconversion emission (662 nm) that can effectively activate Ce6 for in vivo PDT due to the deep tissue penetration of NIR‐II light. This study provides a paradigm of theranostic nanoplatform for both real‐time fluorescence imaging and PDT of orthotopic breast tumor in NIR‐II window.

Funder

National Key Research and Development Program of China

National Natural Science Foundation of China

Publisher

Wiley

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