Affiliation:
1. Department of Cardiac Surgery Guizhou Institute of Precision Medicine, Affiliated Hospital of Guizhou Medical University Guiyang Guizhou 550009 P. R. China
2. Nanjing Stomatological Hospital Affiliated Hospital of Medical School Nanjing University Nanjing 210008 China
3. College of life and health Nanjing Polytechnic Institute Nanjing 210048 China
4. Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) School of Physical and Mathematical Sciences Nanjing Tech University (NanjingTech) Nanjing 211816 China
Abstract
AbstractAntibacterial theranostic nanoplatforms, which integrate diagnostic and therapeutic properties, exhibit gigantic application prospects in precision medicine. However, traditional theranostic nanoplatforms usually present an always‐on signal output, which leads to poor specificity or selectivity in the treatment of bacterial infections. To address this challenge, stimuli‐actuated turn‐on nanoplatforms are developed for simultaneous activation of diagnostic signals (e.g., fluorescent, photoacoustic, magnetic signals) and initiation of antibacterial treatment. Specifically, by combining the infection microenvironment‐responsive activation of visual signals and antibacterial activity, these theranostic nanoplatforms exert both higher accurate diagnosis rates and more effective treatment effects. In this review, the imaging and treatment strategies that are commonly used in the clinic are first briefly introduced. Next, the recent progress of stimuli‐actuated turn‐on theranostic nanoplatforms for treating bacterial infectious diseases is summarized in detail. Finally, current bottlenecks and future opportunities of antibacterial theranostic nanoplatforms are also outlined and discussed.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry