Affiliation:
1. Department of Medicine Ultrasonics Nanfang Hospital Southern Medical University Guangzhou 510515 China
2. Guangdong Provincial Key Laboratory of New Drug Screening School of Pharmaceutical Sciences Southern Medical University Guangzhou 510515 China
3. School of Materials Science and Engineering Sun Yat‐Sen University Guangzhou 510275 China
Abstract
AbstractNanotechnology‐based strategy has recently drawn extensive attention for the therapy of malignant tumors due to its distinct strengths in cancer diagnosis and treatment. However, the limited intratumoral permeability of nanoparticles is a major hurdle to achieving the desired effect of cancer treatment. Due to their superior cargo towing and reliable penetrating property, micro‐/nanomotors (MNMs) are considered as one of the most potential candidates for the coming generation of drug delivery platforms. Here, near‐infrared (NIR)‐actuated biomimetic nanomotors (4T1‐JPGSs‐IND) are fabricated successfully and we demonstrate that 4T1‐JPGSs‐IND selectively accumulate in homologous tumor regions due to the effective homing ability. Upon laser irradiation, hyperthermia generated by 4T1‐JPGSs‐IND leads to self‐thermophoretic motion and photothermal therapy (PTT) to ablate tumors with a deep depth, thereby improving the photothermal therapeutic effect for cancer management. The developed nanomotor system with multifunctionalities exhibits promising potential in biomedical applications to fight against various diseases.
Funder
National Natural Science Foundation of China
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry
Cited by
1 articles.
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