Affiliation:
1. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Biomedical Materials and Engineering Research Center of Hubei Province Wuhan 430070 China
2. College of Life Sciences and Technology Huazhong University of Science & Technology Wuhan 430074 China
3. Department of Pediatric Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China
4. Foshan Xianhu Laboratory of the Advanced Energy Science and Technology Guangdong Laboratory Xianhu Hydrogen Valley Foshan 528200 China
Abstract
AbstractSpinal cord injury (SCI) often leads to cell death, vascular disruption, axonal signal interruption, and permanent functional damage. Currently, there are no clearly effective therapeutic options available for SCI. Considering the inhospitable SCI milieu typified by ischemia, hypoxia, and restricted neural regeneration, a novel injectable hydrogel system containing conductive black phosphorus (BP) nanosheets within a lipoic acid‐modified chitosan hydrogel matrix (LAMC) is explored. The incorporation of tannic acid (TA)‐modified BP nanosheets (BP@TA) into the LAMC hydrogel matrix significantly improved its conductivity. Further, by embedding a bicyclodextrin‐conjugated tazarotene drug, the hydrogel showcased amplified angiogenic potential in vitro. In a rat model of complete SCI, implantation of LAMC/BP@TA hydrogel markedly improved the recovery of motor function. Immunofluorescence evaluations confirmed that the composite hydrogel facilitated endogenous angiogenesis and neurogenesis at the injury site. Collectively, this work elucidates an innovative drug‐incorporated hydrogel system enriched with BP, underscoring its potential to foster vascular and neural regeneration.
Funder
National Natural Science Foundation of China
National Key Research and Development Program of China
Basic and Applied Basic Research Foundation of Guangdong Province
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry