Affiliation:
1. The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital Quzhou Zhejiang 324000 P. R. China
2. State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China
3. College of Pharmacy Wenzhou Medical University Wenzhou 325000 P. R. China
4. Quzhou Institute for Innovation in Resource Chemical Engineering Quzhou 324000 P. R. China
Abstract
AbstractNovel inorganic sonosensitizers with excellent reactive oxygen species (ROS) generation activity and multifunctionality are appealing in sonodynamic therapy (SDT). Herein, amorphous bismuth (Bi)‐doped CoFe‐layered double hydroxide (a‐CoBiFe‐LDH) nanosheets are proposed via crystalline‐to‐amorphous phase transformation strategy as a new type of bifunctional sonosensitizer, which allows ultrasound (US) to trigger ROS generation for magnetic resonance imaging (MRI)‐guided SDT. Importantly, a‐CoBiFe‐LDH nanosheets exhibit much higher ROS generation activity (≈6.9 times) than that of traditional TiO2 sonosensitizer under US irradiation, which can be attributed to the acid etching‐induced narrow band gap, high electron (e−)/hole (h+) separation efficiency and inhibited e−/h+ recombination. In addition, the paramagnetic properties of Fe ion endow a‐CoBiFe‐LDH with excellent MRI contrast ability, making it a promising contrast agent for T2‐weighted MRI. After modification with polyethylene glycol, a‐CoBiFe‐LDH nanosheets can function as a high‐efficiency sonosensitizer to activate p53, MAPK, oxidative phosphorylation, and apoptosis‐related signaling pathways, ultimately inducing cell apoptosis in vitro and tumor ablation in vivo under US irradiation, which shows great potential for clinical cancer treatment.
Funder
National Natural Science Foundation of China
Fundamental Research Funds for the Central Universities of Beijing University of Chemical Technology
Excellent Young Scientists Fund