Affiliation:
1. College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China
2. Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China
3. Department of Rheumatology and Immunology Peking University Third Hospital Beijing 100191 P. R. China
4. College of Life Science and Technology Beijing University of Chemical Technology Beijing 100029 P. R. China
Abstract
AbstractRheumatoid arthritis (RA), a systemic autoimmune disease, poses a significant human health threat. Iguratimod (IGUR), a novel disease‐modifying antirheumatic drug (DMARD), has attracted great attention for RA treatment. Due to IGUR’s hydrophobic nature, there’s a pressing need for effective pharmaceutical formulations to enhance bioavailability and therapeutic efficacy. The high‐gravity nanoprecipitation technique (HGNPT) emerges as a promising approach for formulating poorly water‐soluble drugs. In this study, IGUR nanodrugs (NanoIGUR) are synthesized using HGNPT, with a focus on optimizing various operational parameters. The outcomes revealed that HGNPT enabled the continuous production of NanoIGUR with smaller sizes (ranging from 300 to 1000 nm), more uniform shapes, and reduced crystallinity. In vitro drug release tests demonstrated improved dissolution rates with decreasing particle size and crystallinity. Notably, in vitro and in vivo investigations showcased NanoIGUR’s efficacy in inhibiting synovial fibroblast proliferation, migration, and invasion, as well as reducing inflammation in collagen‐induced arthritis. This study introduces a promising strategy to enhance and broaden the application of poorly water‐soluble drugs.
Funder
National Natural Science Foundation of China
Subject
Biomaterials,Biotechnology,General Materials Science,General Chemistry