Pregnenolone derivatives as potential anti‐lung cancer agents: A combined in silico and in vitro approach
Author:
Affiliation:
1. Department of Chemistry University of Lucknow Lucknow India
2. Department of Applied Science & Humanities, Faculty of Engineering & Technology University of Lucknow Lucknow India
3. Department of Zoology University of Lucknow Lucknow India
Publisher
Wiley
Subject
General Chemistry
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jccs.202200040
Reference17 articles.
1. Synthesis and cytotoxic effect of pregnenolone derivatives with one or two α,β-unsaturated carbonyls and an ester moiety at C-21 or C-3
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3. Experimental and theoretical investigation of synthesized pregnenolone derivatives via palladium catalyzed cross coupling reactions, their anticancer activity against lung cancer cells
4. Interaction of C20-substituted derivative of pregnenolone acetate with copper (II) leads to ROS generation, DNA cleavage and apoptosis in cervical cancer cells: Therapeutic potential of copper chelation for cancer treatment
5. Synthesis, spectroscopic analysis (FT-IR, UV and NMR) and DFT analysis of novel prodrugs of pregnane, their apoptotic activity in cervical cancer cell lines
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