Quantification of asenapine and three metabolites in human plasma using liquid chromatography-tandem mass spectrometry with automated solid-phase extraction: application to a phase I clinical trial with asenapine in healthy male subjects

Author:

Boer Theo1,Meulman Erik1,Meijering Henri1,Wieling Jaap1,Dogterom Peter2,Lass Holger3

Affiliation:

1. QPS Netherlands; Petrus Campersingel 123; 9713; AG; Groningen; The Netherlands

2. Merck Sharp & Dohme; Molenstraat 110; 5340; BH; Oss; The Netherlands

3. Essex Pharma Development GmbH; Im Wirrigen 25; 45731; Waltrop; Germany

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference15 articles.

1. Dopamine receptor binding predicts clinical and pharmacological potencies of antischizophrenic drugs;Creese;Science,1976

2. European Medicines Agency Sycrest asenapine 2010 http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/human/medicines/001177/human_med_001379.jsp&murl=menus/medicines/medicines.jsp&mid=WC0b01ac058001d124&jsenabled=true

3. Food and Drug Administration US Department of Health and Human Services Center for Drug Evaluation and Research Center for Veterinary Medicine Guidance for Industry: Bioanalytical Method Validation 2001 http://www.fda.gov/CDER/GUIDANCE/4252fnl.htm

4. Drug therapy: schizophrenia;Freedman;New England Journal of Medicine,2003

5. Efficacy and safety of asenapine in a placebo- and haloperidol-controlled trial in patients with acute exacerbation of schizophrenia;Kane;Journal of Clinical Psychopharmacology,2010

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