Refined clinical scoring in comparative EAE studies does not enhance the chance to observe statistically significant differences

Author:

Tietz Silvia M.1,Zwahlen Marcel2,Haghayegh Jahromi Neda1,Baden Pascale1,Lazarevic Ivana1,Enzmann Gaby1,Engelhardt Britta1

Affiliation:

1. Theodor Kocher Institute; University of Bern; Bern Switzerland

2. Institute of Social and Preventive Medicine; University of Bern; Bern Switzerland

Funder

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung

Swiss Multiple Sclerosis Society

EU FP7 ITN nEUROinflammation

UniBe Initiator Grant

Publisher

Wiley

Subject

Immunology,Immunology and Allergy

Reference11 articles.

1. The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment;Robinson;Handb. Clin. Neurol.,2014

2. A myelin oligodendrocyte glycoprotein peptide induces typical chronic experimental autoimmune encephalomyelitis in H-2b mice: fine specificity and T cell receptor V beta expression of encephalitogenic T cells;Mendel;Eur. J. Immunol.,1995

3. Acute experimental allergic encephalomyelitis in SJL/J mice induced by a synthetic peptide of myelin proteolipid protein;Sobel;J. Neuropath. Exp. Neurol.,1990

4. T lymphocyte line-mediated experimental allergic encephalomyelitis-a pharmacologic model for testing of immunosuppressive agents for the treatment of autoimmune central nervous system disease;Westarp;J. Pharmacol. Exp. Ther.,1987

5. Experimental autoimmune encephalomyelitis in the mouse;Miller;Curr. Protoc. Immunol.,2007

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