Down-regulation of p16 and MGMT promotes the anti-proliferative and pro-apoptotic effects of 5-Aza-dC and radiation on cervical cancer cells

Author:

Chen Guan-di1,Qian De-ying2,Li Zhi-gang2,Fan Ge-ying2,You Ke-li2,Wu Yi-long13ORCID

Affiliation:

1. Southern Medical University; Guangzhou Guangdong China

2. Department of Gynecology, Guangdong General Hospital; Guangdong Academy of Medical Sciences; Guangzhou Guangdong China

3. Medical Research Centre, Guangdong Lung Cancer Institute, Guangdong General Hospital; Guangdong Academy of Medical Sciences; Guangzhou Guangdong China

Publisher

Wiley

Subject

Cell Biology,Clinical Biochemistry,General Medicine,Biochemistry

Reference34 articles.

1. The prevention of cervical cancer in developing countries;Denny;BJOG,2005

2. Global cancer statistics, 2012;Torre;CA Cancer J Clin,2015

3. E6/E7 oncoproteins of high risk HPV-16 upregulate MT1-MMP, MMP-2 and MMP-9 and promote the migration of cervical cancer cells;Zhu;Int J Clin Exp Pathol,2015

4. Overexpression of HPV16 E6* alters β-integrin and mitochondrial dysfunction pathways in cervical cancer cells;Evans;Cancer Genomics Proteomics,2016

5. Human papillomavirus and cervical cancer;Crosbie;Lancet,2013

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