Influence of the pharmacokinetic profile on the plasma glucose lowering effect of the PPARγ agonist pioglitazone in Wistar fatty rats

Author:

Goto Akihiko1ORCID,Tagawa Yoshihiko1,Kimura Yoshiaki1,Kogame Akifumi1,Moriya Yuu1,Amano Nobuyuki1

Affiliation:

1. Drug Metabolism and Pharmacokinetics Research Laboratories; Takeda Pharmaceutical Co. Ltd; Fujisawa Japan

Publisher

Wiley

Subject

Pharmacology (medical),Pharmaceutical Science,Pharmacology,General Medicine

Reference24 articles.

1. Glycated hemoglobin, plasma glucose, and erythrocyte aging;Beltran Del Rio;Journal of Diabetes Science and Technology,2016

2. PK/PD modelling and beyond: Impact on drug development;Breimer;Pharmaceutical Research,2008

3. Mechanism-based pharmacokinetic-pharmacodynamic modeling: Biophase distribution, receptor theory, and dynamical systems analysis;Danhof;Annual Review of Pharmacology and Toxicology,2007

4. Comparison of four basic models of indirect pharmacodynamic responses;Dayneka;Journal of Pharmacokinetics and Biopharmaceutics,1993

5. Drug Approval Package for ACTOS Pharmacological review Part 1 1999a http://www.accessdata.fda.gov/drugsatfda_docs/nda/99/021073A_Actos_phrmr_P1.pdf

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