Relapsed isolated CNS lymphoma treated with radiotherapy and intrathecal methotrexate followed by high‐dose intravenous methotrexate, rituximab, and temozolomide: A case report

Author:

Rinaldi Ikhwan12ORCID,Muthalib Abdul12,Gondhowiardjo Soehartati3ORCID,Setiawan Tjondro2,Gunawan Andhika4,Susanto Nelly3,Magdalena Lingga3,Winston Kevin5ORCID,Disamantiji Ashila6,Wirawan Bintang6

Affiliation:

1. Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia Jakarta Indonesia

2. Department of Internal Medicine Gading Pluit Hospital Jakarta Indonesia

3. Department of Radiology Gading Pluit Hospital Jakarta Indonesia

4. Department of Nuclear Medicine Gading Pluit Hospital Jakarta Indonesia

5. Hospital Medicine Bhakti Medicare Hospital Cicurug Indonesia

6. Faculty of Medicine Universitas Indonesia Jakarta Indonesia

Abstract

Key Clinical MessageOptimized treatments for relapsed isolated CNS lymphoma (RI‐SCNSL) remains under investigation. Temozolomide combination‐based therapy, which is often used in glioblastoma may be used as potential treatment in RI‐SCNSL.AbstractOne of the most common types of non‐Hodgkin lymphoma (NHL) is diffuse large B‐cell lymphoma (DLBCL). Despite advances in treatment, relapsed isolated CNS lymphoma (RI‐SCNSL) from DLBCL remains an issue. The optimal approach in RI‐SCNSL remains an area of active investigation as currently there is no high level of evidence for the treatments due to lack of randomized studies. In this case report, we present a DLBCL patient with CNS recurrence treated radiotherapy and intrathecal methotrexate (MTX) followed by intravenous high‐dose MTX, rituximab, and temozolomide. To the best of our knowledge, this is the first case report describing RI‐SCNSL treated with the regiments above which also include temozolomide which is used for glioblastoma.

Publisher

Wiley

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