Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry

Author:

Zhou Haihong1,Castro-Perez Jose1,Lassman Michael E.2,Thomas Tiffany3,Li Wenyu1,McLaughlin Theresa1,Dan Xie1,Jumes Patricia4,Wagner John A.4,Gutstein David E.4,Hubbard Brian K.1,Rader Daniel J.5,Millar John S.5,Ginsberg Henry N.3,Reyes-Soffer Gissette3,Cleary Michele1,Previs Stephen F.1,Roddy Thomas P.1

Affiliation:

1. Molecular Biomarkers-PPDM; Merck Sharp & Dohme Corp.; Whitehouse Station NJ USA

2. Clinical Development Laboratory; Merck Sharp & Dohme Corp.; Whitehouse Station NJ USA

3. Columbia University; New York USA

4. Clinical Pharmacology; Merck Sharp & Dohme Corp.; Whitehouse Station NJ USA

5. Division of Translational Medicine and Human Genetics, Perelman School of Medicine; University of Pennsylvania; Philadelphia PA USA

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference28 articles.

1. Lipoprotein(a) as a cardiovascular risk factor: current status;Nordestgaard;Eur. Heart J.,2010

2. Comparison of deuterated leucine, valine, and lysine in the measurement of human apolipoprotein A-I and B-100 kinetics;Lichtenstein;J Lipid Res.,1990

3. Estimating the fractional synthetic rate of plasma apolipoproteins and lipids from stable isotope data;Foster;J. Lipid Res.,1993

4. Studying apolipoprotein turnover with stable isotope tracers: correct analysis is by modeling enrichments;Ramakrishnan;J. Lipid Res.,2006

5. Determination of kinetic parameters of apolipoprotein B metabolism using amino acids labeled with stable isotopes;Parhofer;J. Lipid Res.,1991

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