Differential Pharmacologic Properties of the Two C75 Enantiomers: (+)-C75 Is a Strong Anorectic Drug; (−)-C75 Has Antitumor Activity

Author:

Makowski Kamil12,Mera Paula1,Paredes David2,Herrero Laura1,Ariza Xavier2,Asins Guillermina1,Hegardt Fausto G.1,García Jordi2,Serra Dolors1

Affiliation:

1. Department of Biochemistry and Molecular Biology, Facultat de Farmàcia; Universitat de Barcelona, E-08028 Barcelona, Spain and Institut de Biomedicina de la Universitat de Barcelona (IBUB) and CIBER Fisiopatología de la Obesidad y la Nutrición (CIBERObn), Instituto de Salud Carlos III; Spain

2. Department of Organic Chemistry, Facultat de Química; Universitat de Barcelona, E-08028 Barcelona, Spain and Institut de Biomedicina de la Universitat de Barcelona (IBUB)

Publisher

Wiley

Subject

Organic Chemistry,Spectroscopy,Drug Discovery,Pharmacology,Catalysis,Analytical Chemistry

Reference36 articles.

1. Synthesis and antitumor activity of an inhibitor of fatty acid synthase;Kuhajda;Proc Natl Acad Sci U S A,2000

2. Pharmacological inhibitors of mammalian fatty acid synthase suppress DNA replication and induce apoptosis in tumor cell lines;Pizer;Cancer Res,1998

3. Inhibition of fatty acid synthesis induces programmed cell death in human breast cancer cells;Pizer;Cancer Res,1996

4. Inhibition of fatty acid synthesis delays disease progression in a xenograft model of ovarian cancer;Pizer;Cancer Res,1996

5. Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors;Loftus;Science,2000

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3