Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model

Author:

Lam Kai Heng,Alex Deepa,Lam In Kei,Tsui Stephen Kwok Wing,Yang Zi Feng,Lee Simon Ming Yuen

Publisher

Wiley

Subject

Cell Biology,Molecular Biology,Biochemistry

Reference29 articles.

1. Resveratrol derivative, trans-3,5,4′-trimethoxystilbene, exerts antiangiogenic and vascular-disrupting effects in zebrafish through the downregulation of VEGFR2 and cell-cycle modulation;Alex;J Cell Biochem,2010

2. Antiangiogenic and vascular-targeting activity of the microtubule-destabilizing trans-resveratrol derivative 3,5,4′-trimethoxystilbene;Belleri;Mol Pharmacol,2005

3. Nobiletin from citrus fruit peel inhibits the DNA-binding activity of NF-kappaB and ROS production in LPS-activated RAW 264.7cells;Choi;J Ethnopharmacol,2007

4. Angiogenesis in cancer, vascular, rheumatoid and other disease;Folkman;Nat Med,1995

5. Angiogenic effect of saponin extract from Panax notoginseng on HUVECs in vitro and zebrafish in vivo;Hong;Phytother Res,2009

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