Novel EP4 Receptor Agonist-Bisphosphonate Conjugate Drug (C1) Promotes Bone Formation and Improves Vertebral Mechanical Properties in the Ovariectomized Rat Model of Postmenopausal Bone Loss-Reference-Cited by-同舟云学术

Novel EP4 Receptor Agonist-Bisphosphonate Conjugate Drug (C1) Promotes Bone Formation and Improves Vertebral Mechanical Properties in the Ovariectomized Rat Model of Postmenopausal Bone Loss

Published:2015-03-25 Issue:4 Volume:30 Page:670-680
ISSN:0884-0431
Container-title:Journal of Bone and Mineral Research
language:en
Short-container-title:J Bone Miner Res

Author:

Liu Careesa C¹²,Hu Sally²³,Chen Gang⁴,Georgiou John²,Arns Steve⁴,Kumar Nag S⁴,Young Robert N⁴,Grynpas Marc D¹²³

Affiliation:

1. Institute of Biomaterials and Biomedical Engineering; University of Toronto; Toronto Ontario Canada

2. Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Toronto Ontario Canada

3. Department of Laboratory Medicine and Pathology; University of Toronto; Toronto Ontario Canada

4. Department of Chemistry; Simon Fraser University; Burnaby British Columbia Canada

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1002/jbmr.2382/fullpdf

Reference68 articles.

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3. Osteoporosis;Sambrook;Lancet.,2006

4. Nitrogen-containing bisphosphonates inhibit the mevalonate pathway and prevent post-translational prenylation of GTP-binding proteins, including Ras;Luckman;J Bone Miner Res.,1998

5. Farnesyl pyrophosphate synthase is the molecular target of nitrogen-containing bisphosphonates;Van Beek;Biochem Biophys Res Commun.,1999

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