A Subpopulation of Synovial Fibroblasts Leads to Osteochondrogenesis in a Mouse Model of Chronic Inflammatory Rheumatoid Arthritis

Author:

Miura Yoko1,Ota Shusuke2,Peterlin Matija3,McDevitt Grete4,Kanazawa Satoshi1

Affiliation:

1. Department of Molecular and Cellular Biology; Nagoya City University Graduate School of Medical Sciences; Nagoya Aichi Japan

2. Department of Orthopaedic Surgery; Shizuoka Medical Center; National Hospital Organization; Suntou-gun Shizuoka Japan

3. Departments of Medicine; Microbiology and Immunology; University of California; San Francisco, San Francisco CA USA

4. Department of Microbiology and immunology; Stanford University School of Medicine; Stanford CA USA

Funder

Ministry of Education, Culture, Sports, Science and Technology

Publisher

Wiley

Subject

Orthopedics and Sports Medicine,Endocrinology, Diabetes and Metabolism

Reference38 articles.

1. Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis;Bartok;Immunol Rev,2010

2. MHC class II polymorphisms, autoreactive T-cells, and autoimmunity;Tsai;Front Immunol,2013

3. Costimulation blockade in autoimmunity and transplantation: the CD28 pathway;Adams;J Immunol,2016

4. Synovium infiltrating T cells induce excessive synovial cell function through CD28/B7 pathway in patients with rheumatoid arthritis;Shimoyama;J Rheumatol,1999

5. Antigen-presenting cells containing bacterial peptidoglycan in synovial tissues of rheumatoid arthritis patients coexpress costimulatory molecules and cytokines;Schrijver;Arthritis Rheum,2000

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