Structural elucidation of two novel degradants of lurasidone and their formation mechanisms under free radical‐mediated oxidative and photolytic conditions via liquid chromatography‐photodiode array/ultraviolet‐tandem mass spectrometry and one‐dimensional/two‐dimensional nuclear magnetic resonance spectroscopy-Reference-Cited by-同舟云学术

Structural elucidation of two novel degradants of lurasidone and their formation mechanisms under free radical‐mediated oxidative and photolytic conditions via liquid chromatography‐photodiode array/ultraviolet‐tandem mass spectrometry and one‐dimensional/two‐dimensional nuclear magnetic resonance spectroscopy

Published:2022-06-23 Issue:7 Volume:57 Page:
ISSN:1076-5174
Container-title:Journal of Mass Spectrometry
language:en
Short-container-title:J Mass Spectrom

Author:

Wang Kathy Cheng¹,Guo Qiaohong¹,Kuang Zijian¹,Jin Jianyang¹,Li Dan¹,Chen Wenbin¹,Zhu Wenquan¹²,Li Min¹³^ORCID

Affiliation:

1. Center of Excellence for Modern Analytical Technologies (CEMAT) Huahai Pharmaceutical Co., Ltd. Linhai Zhejiang China

2. Quality Research Department of API Zhejiang Huahai Pharmaceutical Co., Ltd. Linhai Zhejiang China

3. Huahai US, Inc. Somerset New Jersey USA

Publisher

Wiley

Subject

Spectroscopy

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/jms.4871

Reference27 articles.

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2. Pharmacological Profile of Lurasidone, a Novel Antipsychotic Agent with Potent 5-Hydroxytryptamine 7 (5-HT7) and 5-HT1A Receptor Activity

3. ICH Harmonised Tripartite Guideline Q1A (R2).Stability Testing of New Drug Substances and Products. Dated 6 February 2003.

4. ICH Harmonised Tripartite Guideline Q1B.Stability testing: photostability testing of new drug substances and products. Dated 6 November 1996.

5. Scientific considerations of forced degradation studies in ANDA submissions;Maheswaran R;Pharm Tech,2012

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