MYH9-Related Disease: A Novel Prognostic Model to Predict the Clinical Evolution of the Disease Based on Genotype-Phenotype Correlations

Author:

Pecci Alessandro1,Klersy Catherine2,Gresele Paolo3,Lee Kieran J.D.4,De Rocco Daniela5,Bozzi Valeria1,Russo Giovanna6,Heller Paula G.7,Loffredo Giuseppe8,Ballmaier Matthias9,Fabris Fabrizio10,Beggiato Eloise11,Kahr Walter H.A.12,Pujol-Moix Nuria13,Platokouki Helen14,Van Geet Christel15,Noris Patrizia1,Yerram Preethi16,Hermans Cedric17,Gerber Bernhard18,Economou Marina19,De Groot Marco20,Zieger Barbara21,De Candia Erica22,Fraticelli Vincenzo23,Kersseboom Rogier24,Piccoli Giorgina B.25,Zimmermann Stefanie26,Fierro Tiziana3,Glembotsky Ana C.7,Vianello Fabrizio10,Zaninetti Carlo1,Nicchia Elena5,Güthner Christiane27,Baronci Carlo28,Seri Marco29,Knight Peter J.4,Balduini Carlo L.1,Savoia Anna530

Affiliation:

1. Department of Internal Medicine; IRCCS Policlinico San Matteo Foundation and University of Pavia; Pavia Italy

2. Service of Biometry & Statistics; IRCCS Policlinico San Matteo Foundation; Pavia Italy

3. Department of Internal Medicine; Section of Internal and Cardiovascular Medicine, University of Perugia; Perugia Italy

4. Astbury Centre for Structural Molecular Biology; School of Molecular and Cellular Biology, University of Leeds; Leeds United Kingdom

5. Department of Medical Sciences; University of Trieste; Trieste Italy

6. Division of Pediatric Hematology/Oncology; University of Catania; Catania Italy

7. Department of Hematology Research, Instituto de Investigaciones Médicas Alfredo Lanari, UE IDIM-CONICET; University of Buenos Aires; Buenos Aires Argentina

8. Department of Oncology, Azienda “Santobono-Pausilipon”, Pausilipon Hospital; Napoli Italy

9. Pediatric Hematology and Oncology; Hannover Medical School; Hannover Germany

10. Department of Medicine-DIMED; University of Padova Medical School; Padova Italy

11. Department of Hematology-Oncology; Hospital “Città della Salute e Della Scienza”; Torino Italy

12. Department of Paediatrics and Biochemistry; University of Toronto, Division of Hematology/Oncology, The Hospital for Sick Children; Toronto Canada

13. Institut d'Investigació Biomèdica Sant Pau; Universitat Autònoma de Barcelona; Barcelona Spain

14. Haemophilia Centre and Haemostasis Unit; “Aghia Sophia” Children's Hospital; Athens Greece

15. Center for Molecular and Vascular Biology; University of Leuven; Leuven Belgium

16. Department of Internal Medicine; University of Missouri-Columbia School of Medicine; Columbia Missouri

17. Division of Hematology; St-Luc University Hospital; Brussel Belgium

18. Division of Hematology; University Hospital Zurich; Zurich Switzerland

19. Pediatric Hematology; Aristotle University; Thessaloniki Greece

20. Department of Hematology; University Medical Center Groningen; Groningen The Netherlands

21. Department of Pediatrics and Adolescent Medicine; University Medical Center Freiburg; Freiburg; Germany

22. Department of Internal Medicine; Catholic University of Rome; Rome Italy

23. Hematology Unit; Giovanni Paolo II Foundation; Campobasso Italy

24. Department of Clinical Genetics; Erasmus Medical Centre; Rotterdam The Netherlands

25. Department of Clinical and Biological Sciences; University of Torino; Torino Italy

26. Pediatric Hematology and Oncology; J.W. Goethe-University; Frankfurt Germany

27. Department of Medical Oncology and Hematology; Stadtspital Triemli; Zurich Switzerland

28. Department of Pediatric Hematology and Oncology; Pediatric Hospital "Bambino Gesù"; Rome Italy

29. Medical Genetics Unit, Policlinico Sant'Orsola-Malpighi; University of Bologna; Bologna Italy

30. Institute for Maternal and Child Health; IRCCS "Burlo Garofolo"; Trieste Italy

Publisher

Wiley

Subject

Genetics (clinical),Genetics

Reference39 articles.

1. MYH9-related platelet disorders;Althaus;Semin Thromb Hemost,2009

2. MYH-9 related platelet disorders: strategies for management and diagnosis;Althaus;Transfus Med Hemother,2010

3. Expression of the nonmuscle myosin heavy chain IIA in the human kidney and screening for MYH9 mutations in Epstein and Fechtner syndromes;Arrondel;J Am Soc Nephrol,2002

4. Recent advances in the understanding and management of MYH9-related inherited thrombocytopenias;Balduini;Br J Haematol,2011

5. X-ray structures of the apo and MgATP-bound states of Dictyostelium discoideum myosin motor domain;Bauer;J Biol Chem,2000

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