Pharmacokinetic Properties and Human Use Characteristics of an FDA-Approved Intranasal Naloxone Product for the Treatment of Opioid Overdose

Author:

Krieter Philip1,Chiang Nora1,Gyaw Shwe1,Skolnick Phil1,Crystal Roger2,Keegan Fintan3,Aker Julie4,Beck Melissa4,Harris Jennifer4

Affiliation:

1. National Institute on Drug Abuse; National Institutes of Health; Bethesda MD USA

2. Lightlake Therapeutics; New York NY USA

3. Adapt Pharma, Ltd; Dublin Ireland

4. Concentrics Research; Indianapolis IN USA

Funder

Lightlake Therapeutics, Adapt Pharma, and NIDA contracts

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference37 articles.

1. Trends in opioid analgesic abuse and mortality in the United States;Dart;N Engl J Med.,2015

2. Opioid overdose prevention programs providing naloxone to laypersons-United States, 2014;Wheeler;Morbid Mortal Weekly Rep (MMWR),2015

3. Increases in drug and opioid overdose deaths-United States, 2000-2014;Rudd;Morbid Mortal Weekly Rep (MMWR),2016

4. Substance Abuse and Mental Health Services Administration Drug Abuse Warning Network, 2011: National Estimates of Drug-Related Emergency Department Visits Rockville, MD Substance Abuse and Mental Health Services Administration 2013

5. Relationship between nonmedical prescription-opioid use and heroin use;Compton;N Engl J Med,2016

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