Affiliation:
1. Department of Physics Faculty of Physics and Technology University of Plovdiv “Paisii Hilendarski” 24 Tzar Asen Str. Plovdiv 4000 Bulgaria
2. Department of Pharmaceutical Sciences Faculty of Pharmacy Medical University of Plovdiv 15A Vassil Aprilov Blvd Plovdiv 4002 Bulgaria
3. Research Institute Medical University of Plovdiv 15A Vassil Aprilov Blvd Plovdiv 4002 Bulgaria
Abstract
AbstractThe present study aims to investigate the potential of alginate microspheres, formulated by emulsion technique, as a drug delivery system for 5‐Fluorouracil. Three different concentrations of alginate, namely 1%, 2%, and 3%, are used in the synthesis. The spheres are characterized in terms of their size, morphology, process yield, and loading efficiency. Based on these parameters, the model formulated from 1% alginate is chosen and loaded with different concentrations of 5‐Fluorouracil achieving polymer to drug mass ratios 2:1, 4:1, and 6:1. The release process of the drug is completed in 3 h, showing burst effect for all models. The faster release from Model 2:1 is associated with the biggest drug amount and its accumulation on the periphery of the spheres.