Quercetin: A Putative Eco‐friendly Wide Spectrum Antiviral Against Dengue

Abstract

AbstractDengue is a devastating disease that affects people all over the world, yet there are currently no effective medications or antivirals against it. No vaccine or medicine with long‐lasting effects has been developed to treat dengue fever. Mosquito repellents have gained popularity as a dengue preventative strategy because of their simplicity of application and usage. However, this has led to ecosystem deterioration, damage, and bioaccumulation as well as biomagnification of hazardous residues. When they are first introduced, synthetic pesticides do not create a wide range of major issues that are later discovered. Therefore, it has become urgently necessary to look for natural treatments that reduce or combat dengue in order to avoid such pesticides. An environmentally friendly alternative to conventional antivirals is quercetin, a flavinoid derives from plant sources. This research conducts a pilot investigation using computational approaches to examine the interaction between the flavinoid quercetin with the dengue virus envelop protein. According to the findings of the current investigation, quercetin exhibits excellent affinity with the dengue envelops protein. Hence, quercetin can work as a broad‐spectrum, environmentally friendly antiviral because it interacts with many envelop proteins of dengue and related viruses. Additionally, because it is obtained organically, there is no impact to the ecosystem in the immediate area when it degrades. As a result, it can be used as a potent, environmentally safe, and broad‐spectrum antiviral against the illness