Geranylgeranyl diphosphate synthase (GGPPS) regulates non-alcoholic fatty liver disease (NAFLD)-fibrosis progression by determining hepatic glucose/fatty acid preference under high-fat diet conditions

Author:

Liu Jia1,Jiang Shan1,Zhao Yue23,Sun Qian2,Zhang Jingzi1,Shen Di2,Wu Jing2,Shen Ning1,Fu Xiao2,Sun Xitai4,Yu Decai4,Chen Jun4,He Jian4,Shi Tingting4,Ding Yitao4,Fang Lei23,Xue Bin235,Li Chaojun123ORCID

Affiliation:

1. MOE Key Laboratory of Model Animal for Disease Study, Model Animal Research Center; Nanjing University; Nanjing PR China

2. Jiangsu Key Laboratory of Molecular Medicine, School of Medicine; Nanjing University; Nanjing PR China

3. State Key Laboratory of Pharmaceutical Biotechnology; Nanjing University; Nanjing PR China

4. Nanjing Drum Tower Hospital; The Affiliated Hospital of Nanjing University; Nanjing PR China

5. State Key Laboratory of Natural Medicines; China Pharmaceutical University; Nanjing PR China

Publisher

Wiley

Subject

Pathology and Forensic Medicine

Reference51 articles.

1. Nonalcoholic fatty liver disease: an emerging threat to obese and diabetic individuals;Masuoka;Ann N Y Acad Sci,2013

2. Human fatty liver disease: old questions and new insights;Cohen;Science,2011

3. Does nonalcoholic fatty liver disease predispose patients to hepatocellular carcinoma in the absence of cirrhosis?;Guzman;Arch Pathol Lab Med,2008

4. Liver cancer: connections with obesity, fatty liver, and cirrhosis;Marengo;Annu Rev Med,2016

5. Orchestration of metabolism by macrophages;Biswas;Cell Metab,2012

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