Model‐Based Comparison of Dose‐Response Profiles of Tofacitinib in Japanese Versus Western Rheumatoid Arthritis Patients
Author:
Affiliation:
1. Prizer R&D Japan Tokyo Japan
2. Pfizer Inc. Groton Connecticut USA
Funder
Pfizer
Publisher
Wiley
Subject
Pharmacology (medical),Pharmacology
Link
https://onlinelibrary.wiley.com/doi/pdf/10.1002/jcph.1514
Reference29 articles.
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2. LiX JessonM LeeJ et al.Characterization of a potent inhibitor of JAK kinases CP‐690 550 and inhibition of specific JAK/lSTAT pathways at efficacious exposures in a rodent model of arthritis. Poster presented at:15th International Inflammation Research Association Conference; September 21‐24 2008; Chantilly Virginia.
3. Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes
4. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis
5. New insights into the regulation of T cells by γc family cytokines
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