Model‐Based Comparison of Dose‐Response Profiles of Tofacitinib in Japanese Versus Western Rheumatoid Arthritis Patients

Author:

Suzuki Misaki1,Shoji Satoshi1,Miyoshi So1,Krishnaswami Sriram2

Affiliation:

1. Prizer R&D Japan Tokyo Japan

2. Pfizer Inc. Groton Connecticut USA

Funder

Pfizer

Publisher

Wiley

Subject

Pharmacology (medical),Pharmacology

Reference29 articles.

1. A quantitative analysis of kinase inhibitor selectivity

2. LiX JessonM LeeJ et al.Characterization of a potent inhibitor of JAK kinases CP‐690 550 and inhibition of specific JAK/lSTAT pathways at efficacious exposures in a rodent model of arthritis. Poster presented at:15th International Inflammation Research Association Conference; September 21‐24 2008; Chantilly Virginia.

3. Inhibition of JAK kinases in patients with rheumatoid arthritis: scientific rationale and clinical outcomes

4. Anti-inflammatory activity and neutrophil reductions mediated by the JAK1/JAK3 inhibitor, CP-690,550, in rat adjuvant-induced arthritis

5. New insights into the regulation of T cells by γc family cytokines

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