Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019-Reference-Cited by-同舟云学术

Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019

Published:2014-08-11 Issue:6 Volume:136 Page:1445-1457
ISSN:0020-7136
Container-title:International Journal of Cancer
language:en
Short-container-title:Int. J. Cancer

Author:

Vecchio Donatella¹,Daga Antonio²,Carra Elisa²,Marubbi Daniela²³,Raso Alessandro⁴,Mascelli Samantha⁴,Nozza Paolo⁴,Garrè Maria Luisa⁴,Pitto Francesca⁵,Ravetti Jean Louis⁵,Vagge Stefano⁶,Corvò Renzo⁶,Profumo Aldo⁷,Baio Gabriella⁸,Marcello Diana¹,Frosina Guido¹

Affiliation:

1. Mutagenesis Unit; IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro; Genova Italy

2. Gene Transfer Unit; IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro; Genova Italy

3. Department of Experimental Medicine (DIMES); University of Genova; Genova Italy

4. Istituto Giannina Gaslini; Genova Italy

5. Pathological Anatomy and Histology Unit; IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro; Genova Italy

6. Radiation Oncology Unit; IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro; Genova Italy

7. Biopolymers and Proteomics Unit; IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro; Genova Italy

8. Diagnostic Imaging and Interventional Oncology Unit; IRCCS AOU San Martino - IST Istituto Nazionale per la Ricerca sul Cancro; Genova Italy

Funder

Associazione Italiana per la Ricerca sui Tumori Cerebrali del Bambino, Genova, Italy.

Compagnia San Paolo, Turin, Italy

Publisher

Wiley

Subject

Cancer Research,Oncology

Reference15 articles.

1. Glioblastoma and other malignant gliomas: a clinical review;Omuro;JAMA,2013

2. Predictability, efficacy and safety of radiosensitization of glioblastoma-initiating cells by the ATM inhibitor KU-60019;Vecchio;Int J Cancer,2014

3. Preclinical evaluation of a novel ATM inhibitor, KU59403, in vitro and in vivo in p53 functional and dysfunctional models of human cancer;Batey;Mol Cancer Ther,2013

4. ATM kinase inhibition preferentially sensitizes p53-mutant glioma to ionizing radiation;Biddlestone-Thorpe;Clin Cancer Res,2013

5. Inhibition of DNA double-strand break repair by the dual PI3K/mTOR inhibitor NVP-BEZ235 as a strategy for radiosensitization of glioblastoma;Gil del Alcazar;Clin Cancer Res,2014

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