C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly-Reference-Cited by-同舟云学术

C7orf59/LAMTOR4 phosphorylation and structural flexibility modulate Ragulator assembly

Published:2019-07-28 Issue:9 Volume:9 Page:1589-1602
ISSN:2211-5463
Container-title:FEBS Open Bio
language:en
Short-container-title:FEBS Open Bio

Author:

Rasheed Nadia¹²,Lima Tatiani B.¹³,Mercaldi Gustavo F.¹,Nascimento Andrey F.Z.⁴,Silva Ana L.S.¹,Righetto Germanna L.¹,Bar‐Peled Liron⁵,Shen Kuang⁶⁷⁸⁹¹⁰,Sabatini David M.⁶⁷⁸⁹¹⁰,Gozzo Fabio C.³,Aparicio Ricardo³,Smetana Juliana H.C.¹^ORCID

Affiliation:

1. Brazilian Biosciences National Laboratory (LNBio) Brazilian Center for Research in Energy and Materials (CNPEM) Campinas Brazil

2. Institute of Biology University of Campinas Brazil

3. Institute of Chemistry University of Campinas Brazil

4. Brazilian Synchrotron Light Laboratory (LNLS) Brazilian Center for Research in Energy and Materials (CNPEM) Campinas Brazil

5. The Massachusetts General Hospital Cancer Center Boston MA USA

6. Department of Biology Massachusetts Institute of Technology Cambridge MA USA

7. Whitehead Institute for Biomedical Research Cambridge MA USA

8. Howard Hughes Medical Institute Cambridge MA USA

9. Koch Institute for Integrative Cancer Research Cambridge MA USA

10. Broad Institute of Harvard and Massachusetts Institute of Technology Cambridge MA USA

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

Wiley

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12700

Reference60 articles.

1. Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

2. RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs

3. A mammalian protein targeted by G1-arresting rapamycin–receptor complex

4. Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

5. An expanding role for mTOR in cancer

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