PKU mutation p.G46S prevents the stereospecific binding ofl-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain-Reference-Cited by-同舟云学术

PKU mutation p.G46S prevents the stereospecific binding ofl-phenylalanine to the dimer of human phenylalanine hydroxylase regulatory domain

Published:2017-01-21 Issue:2 Volume:7 Page:195-203
ISSN:2211-5463
Container-title:FEBS Open Bio
language:en
Short-container-title:FEBS Open Bio

Author:

Leandro João¹²,Saraste Jaakko¹,Leandro Paula²,Flatmark Torgeir¹

Affiliation:

1. Department of Biomedicine; University of Bergen; Norway

2. Metabolism and Genetics Group; Research Institute for Medicines and Pharmaceutical Sciences (iMed.UL); Faculty of Pharmacy; University of Lisbon; Portugal

Funder

Fundação para a Ciência e a Tecnologia

Universitetet i Bergen

Publisher

Wiley

Subject

General Biochemistry, Genetics and Molecular Biology

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5. Phenylalanine binding is linked to dimerization of the regulatory domain of phenylalanine hydroxylase;Zhang;Biochemistry,2014

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1. Deregulation of phenylalanine biosynthesis evolved with the emergence of vascular plants;Plant Physiology;2021-09-27

2. Modulation of Human Phenylalanine Hydroxylase by 3-Hydroxyquinolin-2(1H)-One Derivatives;Biomolecules;2021-03-19

3. Allosteric deregulation of phenylalanine biosynthesis evolved with the emergence of vascular plants;2019-11-08

4. Simulations of the regulatory ACT domain of human phenylalanine hydroxylase (PAH) unveil its mechanism of phenylalanine binding;Journal of Biological Chemistry;2018-12