Kinetics and inhibition studies of the L205R mutant of cAMP ‐dependent protein kinase involved in Cushing's syndrome-Reference-Cited by-同舟云学术

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Kinetics and inhibition studies of the L205R mutant of cAMP ‐dependent protein kinase involved in Cushing's syndrome

Published:2018-03-11 Issue:4 Volume:8 Page:606-613
ISSN:2211-5463
Container-title:FEBS Open Bio
language:en
Short-container-title:FEBS Open Bio

Author:

Luzi Nicole M.¹,Lyons Charles E.²,Peterson Darrell L.²³⁴,Ellis Keith C.¹²⁴^ORCID

Affiliation:

1. Department of Medicinal Chemistry School of Pharmacy Virginia Commonwealth University Richmond VA USA

2. Massey Cancer Center Virginia Commonwealth University Richmond VA USA

3. Department of Biochemistry and Molecular Biology School of Medicine Virginia Commonwealth University Richmond VA USA

4. Institute for Structural Biology, Drug Discovery, and Development Virginia Commonwealth University Richmond VA USA

Funder

Virginia Commonwealth University

National Institutes of Health

Publisher

Wiley

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12396

Reference16 articles.

1. New developments in the medical treatment of Cushing's syndrome

2. Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

3. Recurrent activating mutation in PRKACA in cortisol-producing adrenal tumors

4. Activating hotspot L205R mutation in PRKACA and adrenal Cushing’s syndrome

5. Recurrent somatic mutations underlie corticotropin-independent Cushing’s syndrome

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1. Merging cultures and disciplines to create a drug discovery ecosystem at Virginia commonwealth university: Medicinal chemistry, structural biology, molecular and behavioral pharmacology and computational chemistry;SLAS Discovery;2023-09

2. Classification of Cushing's syndrome PKAc mutants based upon their ability to bind PKI;Biochemical Journal;2023-06-22

3. The regulation of PKA signaling in obesity and in the maintenance of metabolic health;Pharmacology & Therapeutics;2022-09

4. Displacement of PKA catalytic subunit from AKAP signaling islands drives pathology in Cushing’s syndrome;2021-10-19

5. Gαs–Protein Kinase A (PKA) Pathway Signalopathies: The Emerging Genetic Landscape and Therapeutic Potential of Human Diseases Driven by Aberrant Gαs-PKA Signaling;Pharmacological Reviews;2021-10

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