Indoxyl sulfate, a uremic toxin in chronic kidney disease, suppresses both bone formation and bone resorption

Author:

Watanabe Kenta1,Tominari Tsukasa23,Hirata Michiko2,Matsumoto Chiho2,Hirata Junya4,Murphy Gillian35,Nagase Hideaki36,Miyaura Chisato123,Inada Masaki123

Affiliation:

1. Cooperative Major of Advanced Health Science; Tokyo University of Agriculture and Technology; Koganei Japan

2. Department of Biotechnology and Life Science; Tokyo University of Agriculture and Technology; Koganei Japan

3. Institute of Global Innovation Research; Tokyo University of Agriculture and Technology; Koganei Japan

4. Safety Research Center; Kureha Corporation; Tokyo Japan

5. Department of Oncology; Cancer Research UK; Li Ka Shing Centre; Cambridge Institute; University of Cambridge; UK

6. Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences; Kennedy Institute of Rheumatology; University of Oxford; UK

Funder

Institute of Global Innovation Research in TUAT

Japan Society for the Promotion of Science

Publisher

Wiley

Subject

General Biochemistry, Genetics and Molecular Biology

Reference37 articles.

1. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1;Yamaguchi;Endocr Rev,2000

2. Regulation of osteoblast differentiation by transcription factors;Komori;J Cell Biochem,2006

3. Structure, expression, and regulation of the major noncollagenous matrix proteins of bone;Young;Clin Orthop Relat Res,1992

4. Structure and molecular regulation of bone matrix proteins;Robey;J Bone Miner Res,1993

5. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function;Anderson;Nature,2000

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