Crystal structures of FMN ‐bound and FMN ‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei-Reference-Cited by-同舟云学术

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Crystal structures of FMN ‐bound and FMN ‐free forms of dihydroorotate dehydrogenase from Trypanosoma brucei

Published:2018-03-06 Issue:4 Volume:8 Page:680-691
ISSN:2211-5463
Container-title:FEBS Open Bio
language:en
Short-container-title:FEBS Open Bio

Author:

Kubota Tomomi¹,Tani Osamu¹,Yamaguchi Tomohiko²,Namatame Ichiji²,Sakashita Hitoshi¹,Furukawa Koji¹,Yamasaki Kazuhiko¹

Affiliation:

1. Biomedical Research Institute National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Japan

2. Drug Discovery Research Astellas Pharma Inc. Tsukuba Japan

Funder

Astellas Pharma

Tokyo Institute of Technology

High Energy Accelerator Research Organization

National Institute of Advanced Industrial Science and Technology

University of Tokyo

Publisher

Wiley

Subject

General Biochemistry, Genetics and Molecular Biology

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/2211-5463.12403

Reference50 articles.

1. Targeting Purine and Pyrimidine Metabolism in Human Apicomplexan Parasites

2. Purine and Pyrimidine Pathways as Targets in Plasmodium falciparum

3. Recent Developments in the Medicinal Chemistry and Therapeutic Potential of Dihydroorotate Dehydrogenase (DHODH) Inhibitors

4. On Dihydroorotate Dehydrogenases and Their Inhibitors and Uses

5. Orotic Acid, More Than Just an Intermediate of Pyrimidine de novo Synthesis

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1. Biochemical characterization of Mycobacterium tuberculosis dihydroorotate dehydrogenase and identification of a selective inhibitor;FEBS Letters;2023-06-15

2. Complementing machine learning‐based structure predictions with native mass spectrometry;Protein Science;2022-05-21

3. Recent advances of human dihydroorotate dehydrogenase inhibitors for cancer therapy: Current development and future perspectives;European Journal of Medicinal Chemistry;2022-03

4. Structural and Biochemical Features of Eimeria tenella Dihydroorotate Dehydrogenase, a Potential Drug Target;Genes;2020-12-07

5. Dihydroorotate dehydrogenase inhibitors in anti-infective drug research;European Journal of Medicinal Chemistry;2019-12

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