Phytosphingosine Increases Biosynthesis of Phytoceramide by Uniquely Stimulating the Expression of Dihydroceramide C4-desaturase (DES2) in Cultured Human Keratinocytes

Author:

Choi Hyun Kyung1,Kim Hyun-Ji2,Liu Kwang-Hyeon2,Park Chang Seo1

Affiliation:

1. Department of Chemical Engineering; Dongguk University, 3-26, Pil-dong, Chung-gu; Seoul 100-715 Republic of Korea

2. BK21 Plus Multi-Omics based Creative Drug Research Team, College of Pharmacy and Research Institute of Pharmaceutical Sciences; Kyungpook National University; 80, Daehak-ro, Buk-gu, Daegu 41566 Republic of Korea

Funder

National Coordinating Center for Global Cosmetic R&D

Publisher

Wiley

Subject

Cell Biology,Organic Chemistry,Biochemistry

Reference42 articles.

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2. A rapid method of total lipid extraction and purification;Bligh;Canadian Journal of Biochemistry and Physiology,1959

3. The role of sphingolipid metabolism in cutaneous permeability barrier formation;Breiden;Biochimica et Biophysica Acta,2014

4. Essential role of Elovl4 in very long chain fatty acid synthesis, skin permeability barrier function, and neonatal survival;Cameron;International Journal of Biological Sciences,2007

5. Intercellular and intracellular functions of ceramides and their metabolites in skin (review);Cha;International Journal of Molecular Medicine,2016

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