Identification of Correlative Shifts in Indices of Brain Cholesterol Metabolism in the C57BL6/Mecp2tm1.1BirdMouse, a Model for Rett Syndrome

Author:

Lütjohann Dieter1,Lopez Adam M.2,Chuang Jen-Chieh3,Kerksiek Anja1,Turley Stephen D.2

Affiliation:

1. Institute for Clinical Chemistry and Clinical Pharmacology; University Clinics of Bonn, Sigmund-Freud-Str. 25; 53127 Bonn Germany

2. Department of Internal Medicine; University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd.; Dallas TX 75390-9151 USA

3. Children's Medical Center Research Institute; University of Texas Southwestern Medical Center, 6000 Harry Hines Blvd.; Dallas TX 75390-9060 USA

Funder

Rett Syndrome Research Trust

Publisher

Wiley

Subject

Cell Biology,Organic Chemistry,Biochemistry

Reference60 articles.

1. On the regulatory role of side-chain hydroxylated oxysterols in the brain: Lessons from CYP27A1 transgenic and Cyp27a1−/− mice;Ali;Journal of Lipid Research,2013

2. Cholesterol homeostasis: A key to prevent or slow down neurodegeneration;Anchisi;Frontiers in Physiology,2013

3. Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment;Aqul;The Journal of Neuroscience,2011

4. Neuropathology of Rett syndrome;Armstrong;Journal of Child Neurology,2005

5. Elimination of cholesterol as cholestenoic acid in human lung by sterol 27-hydroxylase: Evidence that most of this steroid in the circulation is of pulmonary origin;Babiker;Journal of Lipid Research,1999

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