Synergistic effects of graphene quantum dots nanocarriers and folic acid targeting agent on enhanced killing of breast cancer cells by tamoxifen

Author:

Ghanbari Narges1,Fam Ashkan Mohammadali1,Salehi Zeinab1,Khodadadi Abbas Ali1,Safarian Shahrokh2

Affiliation:

1. School of Chemical Engineering, College of Engineering, University of Tehran Tehran Iran

2. School of Biology, College of Science, University of Tehran Tehran Iran

Abstract

AbstractIn this study, a new targeted and controlled‐release drug delivery system based on graphene quantum dots (GQDs) was fabricated. The fluorescent GQDs were synthesized via an environmentally‐friendly chemical oxidation method, using graphene oxide (GO) as a precursor and hydrogen peroxide and ammonia solution as oxidants. Folic acid (FA), as a targeting agent, was bound to GQDs through strong amide covalent bindings, and tamoxifen (TMX), as a hydrophobic anticancer drug, was non‐covalently attached to the nanocarrier via π–π stacking bonds. The as‐prepared GQDs and TMX/FA‐GQDs were characterized using field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), Fourier transform infrared spectroscopy (FTIR), UV/Vis spectroscopy (UV/Vis), and photoluminescence spectroscopy (PL). The resulting TMX/GQDs demonstrated pH‐sensitive release behaviour with an overall release of 85% and 58% at pH 5.5 and 7.4, respectively, after 120 h. Also, the MTT assay test performed on MCF‐7 cells presented negligible toxicity of the nanocarriers, even at high concentrations. At the same time, the targeted nanocarrier, TMX/FA‐GQDs, showed much more toxicity towards MCF‐7 cells than the non‐targeted one and free TMX.

Publisher

Wiley

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