Affiliation:
1. Department of Psychology York University Toronto Ontario Canada
2. Rotman Research Institute at Baycrest Hospital Toronto Ontario Canada
3. Department of Psychology University of Toronto Toronto Ontario Canada
4. Cognitive Neurology Research Group Sunnybrook Hospital Toronto Ontario Canada
Abstract
AbstractEvidence suggests that individual hippocampal subfields are preferentially involved in various memory‐related processes. Here, we demonstrated dissociations in these memory processes in two unique individuals with near‐selective bilateral damage within the hippocampus, affecting the dentate gyrus (DG) in case BL and the cornu ammonis 1 (CA1) subfield in case BR. BL was impaired in discriminating highly similar objects in memory (i.e., mnemonic discrimination) but exhibited preserved overall recognition of studied objects, regardless of similarity. Conversely, BR demonstrated impaired general recognition. These results provide evidence for the DG in discrimination processes, likely related to underlying pattern separation computations, and the CA1 in retention/retrieval.
Funder
Natural Sciences and Engineering Research Council of Canada