Cytoplasmic localization of the cell polarity factor scribble supports liver tumor formation and tumor cell invasiveness

Author:

Wan Shan1,Meyer Anne-Sophie2,Weiler Sofia Maria Elisabeth1,Rupp Christian3,Tóth Marcell1,Sticht Carsten4,Singer Stephan1,Thomann Stefan1,Roessler Stephanie1,Schorpp-Kistner Marina5,Schmitt Jennifer1,Gretz Norbert4,Angel Peter5,Tschaharganeh Darjus Felix16,Marquardt Jens7ORCID,Schirmacher Peter1,Pinna Federico1,Breuhahn Kai1ORCID

Affiliation:

1. Institute of Pathology; University Hospital Heidelberg; Heidelberg Germany

2. Institute of Pathology; Universitätsklinikum Erlangen; Erlangen Germany

3. Department of Gastroenterology, Toxicology and Infectious Diseases; University Hospital of Heidelberg; Heidelberg Germany

4. Medical Faculty Mannheim, Medical Research Center; University of Heidelberg; Mannheim Germany

5. Group Tumor and Microenvironment; German Cancer Research Center; Heidelberg Germany

6. Helmholtz-University Group, Cell Plasticity and Epigenetic Remodelling; German Cancer Research Center; Heidelberg Germany

7. Department of Medicine I; Johannes Gutenberg University; Mainz Germany

Funder

German Cancer Aid

Publisher

Wiley

Subject

Hepatology

Reference35 articles.

1. Rewiring cell polarity signaling in cancer;Halaoui;Oncogene,2015

2. Hepatocyte polarity;Treyer;Compr Physiol,2013

3. Signalling to and from tight junctions;Matter;Nat Rev Mol Cell Biol,2003

4. Epithelial organization, cell polarity and tumorigenesis;McCaffrey;Trends Cell Biol,2011

5. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice;Klezovitch;Genes Dev,2004

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