Determination of metformin in rat plasma by HILIC-MS/MS combined with Tecan automation and direct injection

Author:

Zhang Wei1,Han Futian1,Zhao Harry1,Lin Zhongping John1,Huang Qingtao Mike2,Weng Naidong2

Affiliation:

1. Frontage Laboratories, Inc.; 105 Great Valley Parkway; Malvern; PA; 19355; USA

2. Johnson & Johnson Pharmaceutical Research & Development LLC; 1000 Route 202 South; Raritan; NJ; 08869; USA

Publisher

Wiley

Subject

Clinical Biochemistry,Drug Discovery,Pharmacology,Molecular Biology,General Medicine,Biochemistry,Analytical Chemistry

Reference22 articles.

1. Standards of medical care in diabetes - 2009;American Diabetes Association;Diabetes Care,2009

2. Metformin: its botanical background;Bailey;Practical Diabetes International,2004

3. Rapid determination of metformin in human plasma by liquid chromatography-tandem mass spectrometry method;Chen;Journal of Chromatography B,2004

4. LC-MS/MS method using unbonded silica column and aqueous/methanol mobile phase for the simultaneous quantification of a drug candidate and co-administered metformin in rat plasma;Discenza;Journal of Chromatography B,2010

5. Hydrophilic interaction chromatography using silica columns for the retention of polar analytes and enhanced ESI-MS sensitivity;Grumbach;LCGC,2004

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