Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome

Author:

Lundtoft Christian1,Sjöwall Christopher2,Rantapää‐Dahlqvist Solbritt3,Bengtsson Anders A.4,Jönsen Andreas4,Pucholt Pascal1,Wu Yee Ling5,Lundström Emeli6,Eloranta Maija‐Leena1,Gunnarsson Iva6,Baecklund Eva1,Jonsson Roland7,Hammenfors Daniel8,Forsblad‐d'Elia Helena9,Eriksson Per2,Mandl Thomas10,Bucher Sara11,Norheim Katrine B.12,Auglaend Johnsen Svein Joar13,Omdal Roald14,Kvarnström Marika15,Wahren‐Herlenius Marie16,Truedsson Lennart17,Nilsson Bo18,Kozyrev Sergey V.19,Bianchi Matteo19,Lindblad‐Toh Kerstin20,Yu Chack‐Yung21,Nordmark Gunnel1,Sandling Johanna K.1,Svenungsson Elisabet6,Leonard Dag1,Rönnblom Lars1,

Affiliation:

1. Department of Medical Sciences, Rheumatology Uppsala University Uppsala Sweden

2. Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences Linköping University Linköping Sweden

3. Department of Public Health and Clinical Medicine/Rheumatology Umeå University Umeå Sweden

4. Department of Clinical Sciences Lund, Rheumatology, Lund University, and Skåne University Hospital Lund Sweden

5. Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital, Columbus, Ohio, and the Department of Microbiology and Immunology Loyola University Chicago Illinois

6. Division of Rheumatology, Department of Medicine Solna Karolinska Institutet, Karolinska University Hospital Stockholm Sweden

7. Broegelmann Research Laboratory, Department of Clinical Science University of Bergen Bergen Norway

8. Department of Rheumatology Haukeland University Hospital Bergen Norway

9. Department of Rheumatology and Inflammation Research Sahlgrenska Academy, University of Gothenburg Gothenburg Sweden

10. Division of Rheumatology, Department of Clinical Sciences Malmö Lund University, and Novartis Malmö Sweden

11. Department of Rheumatology, Faculty of Medicine and Health Örebro University Örebro Sweden

12. Department of Rheumatology, Stavanger University Hospital, Stavanger, Norway, and the Institute of Clinical Science, University of Bergen Bergen Norway

13. Department of Rheumatology Stavanger University Hospital Stavanger Norway

14. Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen, Bergen, Norway, and the Department of Rheumatology Stavanger University Hospital Stavanger Norway

15. Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, and the Academic Specialist Center, Center for Rheumatology, Stockholm Health Services Stockholm Sweden

16. Division of Rheumatology, Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden, and Broegelmann Research Laboratory, Department of Clinical Science, University of Bergen Bergen Norway

17. Department of Microbiology, Immunology, and Glycobiology Lund University Hospital Lund Sweden

18. Department of Immunology, Genetics, and Pathology Uppsala University Uppsala Sweden

19. Science for Life Laboratory, Department of Medical Biochemistry and Microbiology Uppsala University Uppsala Sweden

20. Science for Life Laboratory, Department of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden, and Broad Institute of MIT and Harvard Cambridge Massachusetts

21. Center for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital Columbus Ohio

Funder

Göran Gustafssons Stiftelse för Naturvetenskaplig och Medicinsk Forskning

Stiftelsen Konung Gustaf V:s 80-årsfond

Hjärt-Lungfonden

Reumatikerförbundet

Svenska Sällskapet för Medicinsk Forskning

Svenska Läkaresällskapet

Publisher

Wiley

Subject

Immunology,Rheumatology,Immunology and Allergy

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