Exploration of the conformational landscape in pregnane X receptor reveals a new binding pocket
Author:
Affiliation:
1. Molecular Biophysics Unit; Indian Institute of Science; Bangalore 560012 India
2. Department of Pharmacology; University of Cambridge; Cambridge United Kingdom
Publisher
Wiley
Subject
Molecular Biology,Biochemistry
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1002/pro.3012/fullpdf
Reference51 articles.
1. Nuclear receptors CAR and PXR: Molecular, functional, and biomedical aspects;Masi;Mol Aspects Med,2009
2. Principles for modulation of the nuclear receptor superfamily;Gronemeyer;Nat Rev Drug Discov,2004
3. Targeting xenobiotic receptors PXR and CAR in human diseases;Banerjee;Drug Discov Today,2015
4. PXR, CAR and drug metabolism;Willson;Nat Rev Drug Discov,2002
5. PXR antagonists and implication in drug metabolism;Mani;Drug Metab Rev,2013
Cited by 10 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献
1. Gefitinib Inhibits Rifampicin-Induced CYP3A4 Gene Expression in Human Hepatocytes;ACS Omega;2022-09-13
2. Discrepancy in interactions and conformational dynamics of pregnane X receptor (PXR) bound to an agonist and a novel competitive antagonist;Computational and Structural Biotechnology Journal;2022
3. Insights into Mechanisms and Models for Studying Neurological Adverse Events Mediated by Pharmacokinetic Interactions between Clinical Drugs and Illicit Substances of Herbal and Fungal Origin;Medicinal Herbs and Fungi;2021
4. Targeting Nuclear Receptors with PROTAC degraders;Molecular and Cellular Endocrinology;2019-08
5. Advances in understanding the regulatory mechanism of cholesterol 7α-hydroxylase;Biochemical Pharmacology;2019-06
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3