Skull base surgery for malignant tumors: The 2nd international collaborative study (1995

Skull base surgery for malignant tumors: The 2nd international collaborative study (1995–2015)

Published:2024-05-21 Issue: Volume: Page:
ISSN:1043-3074
Container-title:Head & Neck
language:en
Short-container-title:Head & Neck

Author:

Shah Jatin P.¹^ORCID,Levyn Helena¹^ORCID,Valero Cristina¹^ORCID,Adilbay Dauren¹,Eagan Alana¹,Zheng Junting²,Gonen Mithat²,Cohen Marc¹^ORCID,Patel Snehal¹,Ganly Ian¹^ORCID,Pai Prathamesh³,Castelnuovo Paolo⁴,Gao Fang Ju⁵,Piazza Cesare⁶,Nicolai Piero⁶,Panizza Ben⁷,Bowman James⁷,Barnett Catherine⁷,Kowalski Luiz P.⁸⁹,Toledo Ronaldo⁸,Fliss Dan M.¹⁰,DeAlmeida John¹¹,Witterick Ian¹¹,Herman Philippe¹²,Fontanella Walter¹³^ORCID,Aniceto Gregorio Sanchez¹⁴^ORCID,Hosal Sefik¹⁵,Ozer Serdar¹⁵,Iyer Subramania¹⁶,Harvey Richard¹⁷^ORCID,Leemans C. Rene¹⁸,Hendrickx Jan‐Jaap¹⁸,Figari Marcelo¹⁹,Boccalatte Luis¹⁹,Nibu Ken Ichi²⁰^ORCID,Clarke Peter²¹,Rennie Catherine²¹,Ming Zhu Yi²²,Cernea Claudio⁹,Goncalves Sergio⁹,Schlosser Rodney²³,Dias Fernando²⁴,Sargi Zoukaa²⁵,Ahmed Shahzada²⁶,Golusinski Wojciech²⁷,Kim Se Heon²⁸^ORCID,Su Shirley Y.²⁹,Raza Shaan M.³⁰,DeMonte Franco³⁰,Hanna Ehab²⁹

Affiliation:

1. Department of Surgery Memorial Sloan Kettering Cancer Center New York New York USA

2. Department of Epidemiology and Biostatistics Memorial Sloan Kettering Cancer Center New York New York USA

3. Head and Neck Surgical Oncology Tata Memorial Hospital Mumbai India

4. Department of Otorhinolaryngology University of Insubria Varese Italy

5. Department of Head and Neck Surgery Beijing Tongren Hospital Beijing China

6. Unit of Otorhinolaryngology – Head and Neck Surgery University of Brescia, Spedali Civili BS Piazzale Spedali Civili Brescia Italy

7. Department of Head & Neck Oncology Princess Alexandra Hospital Woolloongabba Queensland Australia

8. Head and Neck Reference Center, AC Camargo Sao Paulo Brazil

9. Head and Neck Service, ICESP São Paulo Brazil

10. University of Nicosia Medical School Cyprus

11. Department of Otolaryngology – Head & Neck Surgery University Health Network Toronto Ontario Canada

12. ENT Department – Skull Base Center Hispital Lariboisiere APHP Paris France

13. Unit of Otorhinolaryngology – Maxillofacial, and Thyroid Surgery University of Milan Milan Italy

14. Oral and Maxillofacial Department 12 de Octubre University Hospital Madrid Spain

15. Department of Otolaryngology, Head and Neck Surgery, Faculty of Medicine Atılım University, Medicana International Ankara Ankara Turkey

16. Department of Head and Neck Surgery and Oncology Amrita Institute of Medical Sciences Kochi India

17. Sydney Ear Nose Throat Clinic Darlinghurst New South Wales Australia

18. Otolaryngology‐Head and Neck Surgery Amsterdam University Medical Center, VU University Amsterdam The Netherlands

19. Head and Neck Surgery Hospital Italiano de Buenos Aires Buenos Aires Argentina

20. Department of Otolaryngology – Head & Neck Surgery Kobe University Graduate School of Medicine Kobe Japan

21. ENT Department, Imperial College Healthcare NHS Trust Charing Cross Hospital London United Kingdom

22. Head and Neck Surgery Beijing Cancer Center Beijing China

23. Department of Otolaryngology – Head & Neck Surgery Medical University of South Carolina Charleston South Carolina USA

24. Department of Head and Neck Surgery Instituto Nacional de Câncer Rio de Janeiro Brazil

25. Department of Otolaryngology University of Miami Miami Florida USA

26. Department of Otolaryngology – Head and Neck Surgery University of Birmingham, University Hospitals Birmingham Birmingham United Kingdom

27. Department of Head and Neck Surgery The Greater Poland Cancer Centre Poznan Poland

28. Department of ENT Yonsei University Health System Seoul South Korea

29. Department of Head and Neck Surgery MD Anderson Cancer Center Houston Texas USA

30. Department of Neurosurgery MD Anderson Cancer Center Houston Texas USA

Abstract

AbstractBackgroundThe current study presents the effort of a global collaborative group to review the management and outcomes of malignant tumors of the skull base worldwide.Patients and methodsA total of 28 institutions contributed data on 3061 patients. Analysis evaluated clinical variables, survival outcomes, and multivariable factors associated with outcomes.ResultsThe median age was 56 years (IQR 44–67). The open surgical approach was used in 55% (n = 1680) of cases, endoscopic resection was performed in 36% (n = 1087), and the combined approach in 9.6% (n = 294). With a median follow‐up of 7.1 years, the 5‐year OS DSS and RFS were 65%, 71.7% and 53%, respectively. On multivariable analysis, older age, comorbidities, histology, dural/intracranial involvement, positive margins, advanced stage, and primary site were independent prognostic factors for OS, DSS, and RFS. Adjuvant RT was a protective prognostic factor.ConclusionThe progress across various disciplines may have contributed to improved OS and DSS in this study compared to previous reports.

Funder

National Institutes of Health

Publisher

Wiley

Link

https://onlinelibrary.wiley.com/doi/pdf/10.1002/hed.27746

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