Toward a better understanding of depression and anxiety. The importance of tryptophan hydroxylase activation blockade: The origin of a unique anxiolytic antidepressant

Author:

Gittos Maurice W.

Publisher

Wiley

Subject

Drug Discovery

Reference30 articles.

1. Early life blockade of 5-hydroxytryptamine 1A receptors normalizes sleep and depression-like behaviour in adult knock-out mice lacking the serotonin transporter;Alexandre;J Neurosci,2006

2. Amey DA Gittos MW Clerc G Noury J 1985 Tryptophan hydroxylase activation inhibitor for the treatment of anxiety and depression

3. Early-life blockade of the 5-HT transporter alters emotional behaviour in adult mice;Ansorge;Science,2004

4. Boadle-Biber MC The increase in brainstem tryptophan hydroxylase (TRPH) activity induced by depolarization (DEP) or phosphorylating conditions is blocked by 3-(3-methoxyphenyl)-3-(3-dimethylaminopropyl)-4;4-dimethylpiperidine-2,6-di-one (AGN 2979)

5. AGN 2979 [(3-methoxyphenyl)-3-(3-dimethyl-aminopropyl)-4,4-dimethylpiperidine-2,6-dione]. An inhibitor of the activation of tryptophan hydroxylase;Boadle-Biber;Biochem Pharmacol,1986

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