Three-Component Aminoalkylations Yielding Dihydronaphthoxazine-Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side-Chains-Reference-Cited by-同舟云学术

Three-Component Aminoalkylations Yielding Dihydronaphthoxazine-Based Sirtuin Inhibitors: Scaffold Modification and Exploration of Space for Polar Side-Chains

Published:2017-05-26 Issue:7 Volume:350 Page:e1700097
ISSN:0365-6233
Container-title:Archiv der Pharmazie
language:en
Short-container-title:Arch. Pharm. Chem. Life Sci.

Author:

Vojacek Steffen¹,Beese Katja¹,Alhalabi Zayan²,Swyter Sören³,Bodtke Anja¹,Schulzke Carola⁴,Jung Manfred³,Sippl Wolfgang²,Link Andreas¹^ORCID

Affiliation:

1. Institute of Pharmacy; University of Greifswald; Greifswald Germany

2. Institute of Pharmacy; Martin Luther University of Halle-Wittenberg; Halle/Saale Germany

3. Institute of Pharmaceutical Sciences; University of Freiburg; Freiburg Germany

4. Institute of Biochemistry; University of Greifswald; Greifswald Germany

Funder

Deutsche Forschungsgemeinschaft

Publisher

Wiley

Subject

Drug Discovery,Pharmaceutical Science

Reference48 articles.

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2. SIRT1-SIRT3 Axis Regulates Cellular Response to Oxidative Stress and Etoposide

3. SIRT2 Regulates Adipocyte Differentiation through FoxO1 Acetylation/Deacetylation

4. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction

5. Structural Modifications of Benzimidazoles via Multi-Step Synthesis and Their Impact on Sirtuin-Inhibitory Activity

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